The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia.

doi:10.1111/j.1365-2125.2005.02570.x

Article

The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia.

British journal of clinical pharmacology - 1 Mar 2006

Davies Benjamin J, Coller Janet K, James Heather M, Somogyi Andrew A, Horowitz John D, Sallustio Benedetta C

Abstract excerpt

AIMS: CYP2D6 protein expression is determined by the number of functional CYP2D6 alleles. It is also higher in individuals with at least one CYP2D6*2 allele. This study has investigated the effect of the number of functional CYP2D6 alleles and the influence of CYP2D6*2 alleles on plasma perhexili...

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The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia.

Abstract excerpt

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