Article
An age-induced switch to a hyper-recombinational state.
Science (New York, N.Y.) - 26 Sept 2003
McMurray Michael A, Gottschling Daniel E
Abstract excerpt
There is a strong correlation between age and cancer, but the mechanism by which this phenomenon occurs is unclear. We chose Saccharomyces cerevisiae to examine one of the hallmarks of cancer--genomic instability--as a function of cellular age. As diploid yeast mother cells aged, an approximately 100-fold increase in loss of heterozygosity (LOH) occurred. Extending life-span altered neither the onset nor the...
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