Article
Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain.
Oncogene - 25 Sept 2003
Obungu Victor H, Lee Burns A, Agarwal Sunita K, Chandrasekharapa Settara C, Adelstein Robert S, Marx Stephen J
Abstract excerpt
MEN1 is a likely tumor suppressor gene that encodes a novel protein, menin. Menin is a 610 amino-acid residue protein with as yet unknown function(s). We have used tandem affinity purification and mass spectroscopy to isolate and identify proteins associating with menin from cultured HeLa cell extracts. This strategy has resulted in the isolation and identification of nonmuscle myosin type II-A heavy chain (NMHC...
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