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Article

Direct binding of DNA by tumor suppressor menin.

The Journal of biological chemistry - 19 Nov 2004

La Ping, Silva Albert C, Hou Zhaoyuan, Wang Haoren, Schnepp Robert W, Yan Nieng, Shi Yigong, Hua Xianxin

Abstract excerpt

Menin is a tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1), an inherited tumor-prone syndrome. Because there is no obvious conserved structural domain in menin that suggests a biochemical function, little is known as to how menin suppresses tumorigenesis. Although menin interacts with a variety of nuclear proteins including transcription factors, it is unknown whether...

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Identifiers

PMID: 15331604
DOI: 10.1074/jbc.M409358200
PMCID: PMC2858586

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct binding of DNA by tumor suppressor menin.PMID 15331604Read ↗

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Epigenetic regulation by the menin pathwaySemantic proximity Read ↗

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Menin: from molecular insights to clinical impactSemantic proximity Read ↗

Menin, Histone H3 Methyltransferases, and Regulation of Cell Proliferation: Current Knowledge and PerspectiveSemantic proximity Read ↗

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1Semantic proximity Read ↗

Tumor Suppressor Menin Regulates Expression of Insulin-Like Growth Factor Binding Protein 2Semantic proximity Read ↗

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