Article
Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster.
Anesthesiology - 1 Oct 2003
Gamo Sumiko, Tomida Junya, Dodo Katsuyuki, Keyakidani Dai, Matakatsu Hitoshi, Yamamoto Daisuke, Tanaka Yoshiharu
Abstract excerpt
BACKGROUND: Various species, e.g., Caenorhabditis elegans, Drosophila melanogaster, and mice, have been used to explore the mechanisms of action of general anesthetics in vivo. The authors isolated a Drosophila mutant, ethas311, that was hypersensitive to diethylether and characterized the calreticulin (crc) gene as a candidate of altered anesthetic sensitivity. METHODS: Molecular analysis of crc included cloning...
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