Article
Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster.
Anesthesiology - 1 Oct 2003
Gamo Sumiko, Tomida Junya, Dodo Katsuyuki, Keyakidani Dai, Matakatsu Hitoshi, Yamamoto Daisuke, Tanaka Yoshiharu
Abstract excerpt
BACKGROUND: Various species, e.g., Caenorhabditis elegans, Drosophila melanogaster, and mice, have been used to explore the mechanisms of action of general anesthetics in vivo. The authors isolated a Drosophila mutant, ethas311, that was hypersensitive to diethylether and characterized the calreticulin (crc) gene as a candidate of altered anesthetic sensitivity. METHODS: Molecular analysis of crc included cloning...
Topics
- Anesthetics
- Animals
- Animals, Genetically Modified
- Calreticulin
- Dose-Response Relationship, Drug
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression Regulation, Developmental
- Male
- Mutation
- Phenotype
- RNA, Messenger