Article
Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003
Tsuji Takashi, Hidaka Shigekazu, Sawai Terumitsu, Nakagoe Tohru, Yano Hiroshi, Haseba Masatoshi, Komatsu Hideaki, Shindou Hisakazu, Fukuoka Hidetoshi, Yoshinaga Megumi, Shibasaki Shinichi, Nanashima Atsushi, Yamaguchi Hiroyuki, Yasutake Tohru, Tagawa Yutaka
Abstract excerpt
Thymidylate synthase (TS) is the target enzyme of 5-fluoropyrimidines. The TS gene promoter enhancer region (TSER) possesses tandem, repeated, regulatory sequences that are polymorphic in humans. This polymorphism has been reported to influence TS expression in vitro and in vivo. In this study, we assessed whether or not the TSER genotype is an efficacious marker for tumor sensitivity to 5-fluorouracil...
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