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Article

Laminin-332 (Laminin-5) is the major motility ligand for B cell chronic lymphocytic leukemia.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jul 2007

Spessotto Paola, Zucchetto Antonella, Degan Massimo, Wasserman Bruna, Danussi Carla, Bomben Riccardo, Perris Roberto, Canzonieri Vincenzo, Radillo Oriano, Colombatti Alfonso, Gattei Valter

Abstract excerpt

Cell adhesion and motility are central aspects in the pathophysiology of B cell chronic lymphocytic leukemia (B-CLL), but the role of specific extracellular matrix proteins is still to be completely unveiled. Purified peripheral blood neoplastic cells of B-CLL patients migrated poorly on laminins-111,-411,-511, but showed pronounced motility on laminin (LM)-332 in a high percentage of cases. B-CLL cell motility...

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Identifiers

PMID: 17482449
DOI: 10.1016/j.matbio.2007.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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