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Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faecium.

Antimicrobial agents and chemotherapy - 1 Oct 2003

Willems Rob J, Top Janetta, Smith Derek J, Roper David I, North Sarah E, Woodford Neil

Abstract excerpt

Mutations in mutS and mutL, which encode DNA mismatch repair (MMR) proteins, can confer hypermutator phenotypes and may facilitate the emergence of mutational antibiotic resistance in bacteria. Linezolid-resistant enterococci (LRE) rarely emerge during therapy and contain mutations in 23S rRNA genes. As enterococci with defective MMR could be prone to the development of oxazolidinone resistance mutations, we...

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Identifiers

PMID: 14506009
DOI: 10.1128/AAC.47.10.3061-3066.2003
PMCID: PMC201155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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