Article
Factor V Leiden mutation accelerates the onset of natural menopause.
Menopause (New York, N.Y.) - 1 Jan 2000
van Asselt Kristel M, Kok Helen S, Peeters Petra H M, Roest Mark, Pearson Peter L, te Velde Egbert R, Grobbee Diederick E, van der Schouw Yvonne T
Abstract excerpt
OBJECTIVE: Smoking is consistently associated with a younger age for menopause. Although this may be because of the direct toxic effects of tobacco smoke on follicles, we hypothesize that there may also be a relationship between smoking and a vascular origin of early menopausal onset. Several lifestyle factors have been investigated, but never factors of the clotting cascade. The objective of this study, then,...
Topics
- Factor V
- Female
- Gene Frequency
- Humans
- Menopause
- Middle Aged
- Mutation
- Polymorphism, Genetic
- Smoking