Article
Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis.
Infection and immunity - 1 Oct 2003
Spellberg Brad, Johnston Douglas, Phan Quynh Trang, Edwards John E, French Samuel W, Ibrahim Ashraf S, Filler Scott G
Abstract excerpt
We examined the relationship between host survival and renal and splenic immune responses in a murine model of hematogenously disseminated candidiasis. Male BALB/c mice were infected via tail vein injection with wild-type C. albicans or with an isogenic, Deltaefg1/Deltaefg1 hypha-deficient mutant. Host survival, organ fungal burden, intracellular cytokine content of splenic and kidney lymphocytes, and whole-organ...
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