Article
Systemic infection following intravenous inoculation of mice with Candida albicans int1 mutant strains.
Molecular genetics and metabolism - 1 Aug 1999
Bendel C M, Kinneberg K M, Jechorek R P, Gale C A, Erlandsen S L, Hostetter M K, Wells C L
Abstract excerpt
The Candida albicans gene INT1 is associated with epithelial adhesion, hyphal formation, and virulence. C. albicans strains carrying two, one, or no functional INT1 alleles were used to assess the association between mortality and C. albicans persistence in the liver and kidney of intravenously inoculated mice. Mice were injected with 10(5) C. albicans CAF2 (parent strain, INT1/INT1), C. albicans CAG3 (homozygous...
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