Article
Importance of the cytochrome P450 2D6 genotype for the drug metabolic interaction between chlorpromazine and haloperidol.
Therapeutic drug monitoring - 1 Aug 2001
Suzuki Y, Someya T, Shimoda K, Hirokane G, Morita S, Yokono A, Inoue Y, Takahashi S
Abstract excerpt
The authors studied the interactive effects of the coadministration of haloperidol and chlorpromazine on plasma concentrations of haloperidol and reduced haloperidol. The subjects were 43 Japanese male schizophrenic inpatients who were concomitantly treated with chlorpromazine before or after monotherapy with haloperidol. Coadministration of chlorpromazine produced significant increases in the plasma...
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