Article
The metabolism of host RNAs in cells infected by an adenovirus E4 mutant.
Virology - 1 Mar 1991
Sandler A B, Ketner G
Abstract excerpt
Mutants of adenovirus type 5 (Ad5) that lack early region 4 (E4) are defective in the expression of viral late genes. E4 mutants exhibit dramatically reduced levels of both cytoplasmic and nuclear viral late RNAs compared to wild-type virus, due principally to reduced stability of unprocessed viral late RNA in the nucleus of mutant-infected cells. To determine whether E4 products also affect the metabolism of...
Topics
- Adenoviruses, Human
- Cell Nucleus
- Cell Transformation, Viral
- Chromosome Deletion
- Defective Viruses
- HeLa Cells
- Mutation
- Plasmids
- RNA, Neoplasm