Article
Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein.
The Journal of biological chemistry - 5 Dec 1992
West A H, Clark D J, Martin J, Neupert W, Hartl F U, Horwich A L
Abstract excerpt
The processing enhancing protein of mitochondria (PEP) is an essential component that has been shown to participate in proteolytic removal of NH2-terminal signal peptides from precursor proteins imported into the mitochondrial matrix. Using a yeast strain bearing a PEP mutation that renders it te...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Fungal
- DNA, Fungal
- Genes, Fungal
- Genes, Lethal
- Genes, Suppressor
- Genotype
- Mitochondria
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Peptides
- Plasmids
- Protein Conformation
- Restriction Mapping
- Saccharomyces cerevisiae
- Sequence Deletion