Article
Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit.
Biochemistry international - 1 Sept 1992
Sudo K, Maekawa M, Shioya M, Ikeda K, Takahashi N, Isogai Y, Li S S, Kanno T, Machida K, Toriumi J
Abstract excerpt
An electrophoretic variant of lactate dehydrogenase-A (M) subunit was discovered in a patient with multiple myeloma. DNA analysis of the variant allele revealed a nucleotide substitution (transition) of C to T at codon 314 (CGT-TGT), and this mutation resulted in the replacement of an arginine by...
Topics
- Aged
- Amino Acid Sequence
- Animals
- Electrophoresis
- Female
- Humans
- Isoenzymes
- L-Lactate Dehydrogenase
- Molecular Sequence Data
- Multiple Myeloma
- Mutation
- Polymerase Chain Reaction
- Sequence Homology, Nucleic Acid