Article
HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID).
Clinical and experimental immunology - 1 Jun 1999
De La Concha E G, Fernandez-Arquero M, Martinez A, Vidal F, Vigil P, Conejero L, Garcia-Rodriguez M C, Fontan G
Abstract excerpt
Most cases of CVID occur sporadically, but familial cases do also occur and 15% of the patients with the disease have first degree relatives with IgA deficiency (IgAD). Our purpose was to study CVID association with HLA class II alleles and to ascertain whether this disease shares a common genetic background with IgAD in our population. Patients with CVID (n = 42), were typed using gene amplification and...
Topics
- Alleles
- Antigenic Variation
- Case-Control Studies
- Common Variable Immunodeficiency
- Genes, MHC Class II
- HLA Antigens
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Homozygote
- Humans
- IgA Deficiency