Article
Genetics of synchronous uterine and ovarian endometrioid carcinoma: combined analyses of loss of heterozygosity, PTEN mutation, and microsatellite instability.
Human pathology - 1 Apr 2002
Fujii Hiroaki, Matsumoto Toshiharu, Yoshida Manabu, Furugen Yoshiaki, Takagaki Tetsuya, Iwabuchi Keiichi, Nakata Yasuo, Takagi Yoshitake, Moriya Takuya, Ohtsuji Naomi, Ohtsuji Mareki, Hirose Sachiko, Shirai Toshikazu
Abstract excerpt
Synchronous development of carcinomas in the endometrium and ovaries is a fairly common phenomenon, but distinction of a single clonal tumor with metastasis from 2 independent primary tumors may present diagnostic problems. To determine clonality and the occurrence of progression, we microdissected multiple foci from 17 cases of synchronous endometrioid carcinomas and studied loss of heterozygosity (LOH),...
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