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Article

Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype.

The Journal of clinical investigation - 1 Nov 1992

Chen B, Polunovsky V, White J, Blazar B, Nakhleh R, Jessurun J, Peterson M, Bitterman P

Abstract excerpt

After acute lung injury, mesenchymal cells migrate into the alveolar airspace where they proliferate and deposit connective tissue macromolecules. Early in the disease process, inflammatory cell-derived trophic factors modulate these mesenchymal cell functions. However, in those patients who die, even as the inflammatory response abates, the fibroproliferative response continues, resulting in extensive...

Topics

Acute Disease
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Genes, fos
Humans
Lung
Lung Diseases
Mesoderm
Phenotype
Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1430204
DOI: 10.1172/JCI116052
PMCID: PMC443236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1430204-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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