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Article

Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype.

The Journal of clinical investigation - 1 Nov 1992

Chen B, Polunovsky V, White J, Blazar B, Nakhleh R, Jessurun J, Peterson M, Bitterman P

Abstract excerpt

After acute lung injury, mesenchymal cells migrate into the alveolar airspace where they proliferate and deposit connective tissue macromolecules. Early in the disease process, inflammatory cell-derived trophic factors modulate these mesenchymal cell functions. However, in those patients who die, even as the inflammatory response abates, the fibroproliferative response continues, resulting in extensive...

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Identifiers

PMID: 1430204
DOI: 10.1172/JCI116052
PMCID: PMC443236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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