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Cell cycle dependence of ACE-2 explains downregulation in idiopathic pulmonary fibrosis

25 Oct 2012

Abstract excerpt

Alveolar epithelial type II cells, a major source of angiotensin-converting enzyme (ACE)-2 in the adult lung, are normally quiescent but actively proliferate in lung fibrosis and downregulate this protective enzyme. It was, therefore, hypothesised that ACE-2 expression might be related to cell cycle progression. To test this hypothesis, ACE-2 mRNA levels, protein levels and enzymatic activity were examined in...

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Share to Inhalation and Respiratory Drug Delivery
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Pulmonary Hypertension Research and Treatments

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PMID: 23100504
DOI: 10.1183/09031936.00015612

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