Article
Apparent HLA DR triplet due to the coexpression of a DRB5-encoded molecule on a DR1 haplotype.
Human immunology - 1 Jun 1992
Gebuhrer L, Tiercy J M, Freidel A C, Labonne M P, Lambert J, Jeannet M, Betuel H
Abstract excerpt
HLA DR1 molecules are coded by a single polymorphic DRB1 gene. We have observed rare DR1 cells in one Caucasoid family and three unrelated individuals that also reacted with some anti-DR2 sera. Since the second DR antigen was normally expressed, these cells appeared as triplets. Contrary to serol...
Topics
- Adult
- Alleles
- Base Sequence
- Child
- Cross Reactions
- Exons
- Genes, MHC Class II
- HLA-DR Antigens
- HLA-DR1 Antigen
- HLA-DRB5 Chains
- Haplotypes
- Humans
- Male
- Molecular Sequence Data
- Pedigree
- Polymerase Chain Reaction
- Recombination, Genetic
- White People