Article
Search for Ha-ras codon 61 mutations in liver tumours caused by hexachlorobenzene and Aroclor 1254 in C57BL/10ScSn mice with iron overload.
Carcinogenesis - 1 Oct 1992
Rumsby P C, Evans J G, Phillimore H E, Carthew P, Smith A G
Abstract excerpt
C57BL/10ScSn mice administered iron--dextran and fed the environmental pollutants hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) develop hepatic nodules and carcinomas within 18 months. A range of lesions from the livers were analysed for the presence of mutations in the Ha-ras prot...
Topics
- Animals
- Aroclors
- Carcinogens
- Chlorodiphenyl (54% Chlorine)
- Cocarcinogenesis
- Codon
- Dose-Response Relationship, Drug
- Genes, ras
- Hexachlorobenzene
- Iron
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Polymerase Chain Reaction