Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).

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Article

Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).

Blood - 1 Nov 1992

Morishita E, Saito M, Kumabashiri I, Asakura H, Matsuda T, Yamaguchi K

Abstract excerpt

A congenitally dysfunctional form of prothrombin, Prothrombin Himi, shows reduced fibrinogen clotting activity, although it retains full hydrolytic activity toward synthetic substrates. To elucidate the structural abnormality of the variant prothrombin, we first performed genetic analysis of dysprothrombin. Polymerase chain reaction amplification of the exons 8 through 14 of the proband and her family members'...

Topics

Amino Acid Sequence
Arginine
Base Sequence
DNA
Exons
Female
Genetic Carrier Screening
Histidine
Humans
Leukocytes
Male
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Pedigree

Polymerase Chain Reaction

Prothrombin

Source

Open in PubMed

Identifiers

PMID: 1421398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1421398-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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