Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation.

Thrombosis and haemostasis - 28 Feb 2017

Ding Qiulan, Yang Likui, Zhao Xiaoqing, Wu Wenman, Wang Xuefeng, Rezaie Alireza R

Abstract excerpt

We have characterised the pathogenic basis of dysprothrombinaemia in a patient exhibiting paradoxical bleeding and thrombotic defects during pregnancy and postpartum. Genetic analysis revealed that the proband is homozygous for the prothrombin Arg382His mutation, possessing only ~1 % clotting activity. The proband experienced severe bleeding episodes during her pregnancy, which required treatment with prothrombin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation Disorders, Inherited
Share to Blood Coagulation Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carboxypeptidase B2

Share to Fibrinolysis

Share to Pregnancy Complications, Hematologic

Share to Protein C

Share to Pulmonary Embolism

Share to Venous Thromboembolism

Source

Open in PubMed Open full text

Identifiers

PMID: 27975099
DOI: 10.1160/TH16-10-0750
PMCID: PMC5330935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation.PMID 27975099Read ↗

Congenital prothrombin deficiency: an update.Semantic proximity Read ↗

Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment.Semantic proximity Read ↗

Phenotypic and genetic analysis of dysprothrombinemia due to a novel homozygous mutation.Semantic proximity Read ↗

Heterozygous Prothrombin Mutation-Associated Thrombophilia.Semantic proximity Read ↗

Phenotype, genotype, and laboratory assessment of congenital fibrinogen disorders: Data from the Rare Bleeding disorders in the Netherlands study.Semantic proximity Read ↗

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.Semantic proximity Read ↗

Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia.Semantic proximity Read ↗

Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).Semantic proximity Read ↗

Congenital Prothrombin DeficiencySemantic proximity Read ↗

Congenital prothrombin defects: they are not only associated with bleeding but also with thrombosis: a new classification is needed.Semantic proximity Read ↗

Prothrombin gene variants in non-Caucasians with fetal loss and intrauterine growth retardation.Semantic proximity Read ↗

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.