Article
The value of measurement of ras oncogenes and nuclear DNA analysis in the diagnosis of Hürthle cell tumors of the thyroid.
World journal of surgery - 1 Jan 2000
Schark C, Fulton N, Yashiro T, Stanislav G, Jacoby R, Straus F H, Dytch H, Bibbo M, Kaplan E L
Abstract excerpt
Hürthle cell tumors (HCT) remain difficult to treat because some which appear non-malignant on light microscopy later metastasize. In order to improve diagnostic accuracy, the value of ras mutations and nuclear DNA analysis was determined in 65 patients with HCT. Rapid nuclear DNA cytometry (MicroTICAS system) was performed. Mutations of H-ras, K-ras, and N-ras genes were analyzed by oligonucleotide probe...
Topics
- Adult
- Carcinoma
- DNA, Neoplasm
- Female
- Follow-Up Studies
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Metastasis
- Polymerase Chain Reaction