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Article

Resistance of mature T cells to oncogene transformation

19 Jun 2008

Abstract excerpt

Leukemia caused by retroviral insertional mutagenesis after stem cell gene transfer has been reported in several experimental animals and in patients treated for X-linked severe combined immunodeficiency. Here, we analyzed whether gene transfer into mature T cells bears the same genotoxic risk. To address this issue in an experimental "worst case scenario," we transduced mature T cells and hematopoietic...

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PMID: 18566328
DOI: 10.1182/blood-2007-12-128751

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