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Article

Isolation of radiosensitive and radioresistant mutants from a medulloblastoma cell line.

Brain tumor pathology - 1 Jan 1997

Tsuboi K, Tsuchida Y, Endo K, Yoshii Y, Nose T

Abstract excerpt

Two mutant clones, one radiosensitive (OS-3) and one resistant (OR-5), were isolated from ONS-76 after screening 2400 clones by the replica micro-well technique. These two clones exhibited significantly different radiosensitivity, with D37 values of 4.7Gy in OR-5 and 1.7Gy in OS-3. After gamma irradiation (8Gy), OR-5 exhibited greater G2 arrest than sensitive clone OS-3. Administration of 5mM of caffeine resulted...

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Identifiers

PMID: 9384798
DOI: 10.1007/BF02478864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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