Article
Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras.
Infection and immunity - 1 Nov 1992
Jobling M G, Holmes R K
Abstract excerpt
Cholera enterotoxin (CT) is produced by Vibrio cholerae and excreted into the culture medium as an extracellular protein. CT consists of one A polypeptide and five B polypeptides associated by noncovalent bonds, and CT-B interacts with CT-A primarily via the A2 domain. Treatment of CT with trypsi...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Cholera Toxin
- Cloning, Molecular
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Recombinant Fusion Proteins
- Structure-Activity Relationship