Article
Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast.
Genetics - 1 Sept 1992
Hollingsworth R E, Ostroff R M, Klein M B, Niswander L A, Sclafani R A
Abstract excerpt
The Saccharomyces cerevisiae CDC7 gene encodes a protein kinase that functions in DNA replication, repair, and meiotic recombination. The sequence of several temperature-sensitive (ts) cdc7 mutations was determined and correlated with protein kinase consensus domain structure. The positions of these ts alleles suggests some general principles for predicting ts protein kinase mutations. Pedigree segregation lag...
Topics
- Alleles
- Base Sequence
- Cell Cycle Proteins
- Cloning, Molecular
- Fungal Proteins
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutagenesis, Site-Directed
- Mutation
- Protein Kinases
- Protein Serine-Threonine Kinases