Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against alpha 2-adrenoceptor mediation.

doi:10.1007/BF02245943

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Article

Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against alpha 2-adrenoceptor mediation.

Psychopharmacology - 1 Apr 1995

Cole J C, Burroughs G J, Laverty C R, Sheriff N C, Sparham E A, Rodgers R J

Abstract excerpt

The influence of alpha 2-adrenoceptor antagonists in animal models of anxiety is quite inconsistent, with results spanning the full range of effect from anxiogenesis to anxiolysis. In the present study, an ethological technique was used to examine the effects of yohimbine (0.5-4.0 mg/kg) on plus-...

Topics

Animals
Anxiety
Behavior, Animal
Clonidine
Dioxanes
Genotype
Idazoxan
Imidazoles
Mice
Mice, Inbred Strains
Receptors, Adrenergic, alpha-2
Yohimbine

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