Article
Spo0A activates and represses its own synthesis by binding at its dual promoters.
Biochimie - 1 Jan 2000
Strauch M A, Trach K A, Day J, Hoch J A
Abstract excerpt
The Spo0A protein of Bacillus subtilis controls the onset of sporulation by regulating transcription of various genes in both positive and negative manners depending on the promoters affected. The expression of the spo0A gene occurs from two promoters (Pv,Ps), separated by 148 bp, and transcription switches from Pv to Ps early in the sporulation program. DNase I footprint analysis of the spo0A promoter region...
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