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Article

Promoter activation by repositioning of RNA polymerase.

Journal of bacteriology - 1 May 2008

Kumar Amrita, Moran Charles P

Abstract excerpt

Spo0A, a classical two-component-type response regulator in Bacillus subtilis, binds to a specific DNA sequence found in many promoters to repress or activate the transcription of over 100 genes. On the spoIIG promoter, one of the Spo0A binding sites, centered at position -40, overlaps a consensus -35 element that may also interact with region 4 of the sigma A (sigma(A)) subunit of RNA polymerase. Molecular...

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Identifiers

PMID: 18296515
DOI: 10.1128/JB.00096-08
PMCID: PMC2347386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Promoter activation by repositioning of RNA polymerase.PMID 18296515Read ↗

Spo0A mutants of Bacillus subtilis with sigma factor-specific defects in transcription activation.Semantic proximity Read ↗

Evidence that the transcriptional activator Spo0A interacts with two sigma factors in Bacillus subtilis.Semantic proximity Read ↗

Spo0A activates and represses its own synthesis by binding at its dual promoters.Semantic proximity Read ↗

Activation of the Bacillus subtilis spoIIG promoter requires interaction of Spo0A and the sigma subunit of RNA polymerase.Semantic proximity Read ↗

A region in the Bacillus subtilis transcription factor Spo0A that is important for spoIIG promoter activation.Semantic proximity Read ↗

Dimer form of phosphorylated Spo0A, a transcriptional regulator, stimulates the spo0F transcription at the initiation of sporulation in Bacillus subtilis.Semantic proximity Read ↗

Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia.Semantic proximity Read ↗

Spo0A can efficiently enhance the expression of the alkaline protease gene aprE in Bacillus licheniformis by specifically binding to its regulatory region.Semantic proximity Read ↗

Mutational analysis of conserved residues in the putative DNA-binding domain of the response regulator Spo0A of Bacillus subtilis.Semantic proximity Read ↗

Conservation of sigma-core RNA polymerase proximity relationships between the enhancer-independent and enhancer-dependent sigma classes.Semantic proximity Read ↗

Lessons and questions from the structure of the Spo0A activation domain.Semantic proximity Read ↗

Similar organization of the sigB and spoIIA operons encoding alternate sigma factors of Bacillus subtilis RNA polymerase.Semantic proximity Read ↗

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