Article
Mutational dissociation of the positive and negative regulatory properties of the Spo0A sporulation transcription factor of Bacillus subtilis.
Gene - 1 Apr 1991
Perego M, Wu J J, Spiegelman G B, Hoch J A
Abstract excerpt
The Spo0A regulatory protein controls the onset of stationary phase and sporulation by controlling transcription in both a negative and a positive manner depending on the promoter affected. Missense mutations, e.g., spo0A9V, which result in alterations in the eleventh amino acid preceding the C terminus of the Spo0A protein, give rise to a protein active as a negative regulator of the abrB gene but unable to...
Read the complete abstract on PubMedTopics
- Amino Acid Sequence
- Bacillus subtilis
- Bacterial Proteins
- Cloning, Molecular
- Genes, Suppressor
- Genotype