Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme.

doi:10.1021/bi00155a030

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Article

Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme.

Biochemistry - 13 Oct 1992

Mao S S, Holler T P, Bollinger J M, Yu G X, Johnston M I, Stubbe J

Abstract excerpt

Ribonucleotide reductase (RDPR) from Escherichia coli is composed of two subunits, R1 and R2, both of which are required to catalyze the conversion of nucleotides to deoxynucleotides. This reduction process is accompanied by oxidation of two cysteines within the active site to a disulfide. One of...

Topics

Catalysis
Escherichia coli
Free Radicals
Kinetics
Mutation
Nucleotides
Oxidation-Reduction
Ribonucleoside Diphosphate Reductase
Tyrosine
Uridine Diphosphate

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