Article
Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus production.
Journal of virology - 1 Sept 2005
Jayan Geetha C, Casey John L
Abstract excerpt
RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV replication cycle. Editing is required for production of the viral protein hepatitis delta antigen long form (HDAg-L), which is necessary for viral particle production but can inhibit HDV RNA replication. The RNA secondary structural features in ADAR1 substrates are...
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