Article

Clinical, Biological and Pathological Investigation of Bovine Lymphocyte Intestinal Retention Deficit (BLIRD): a new genetic disorder affecting life expectancy and immunity in Holstein dairy cattle

2025-05-21

Abstract excerpt

Dozens of missed recessive loci affecting homozygous carriers’ life expectancy were recently reported. This article details the clinical, biological and pathological manifestations of a new bovine genetic disorder caused by an ITGB7 p.G375S point mutation in the French Holstein cattle breed. Our thorough study involved database analysis of genotyped cattle and a series of case-control investigations of forty homoz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4ca7e1cd-fb2d-5c51-9b53-a6e380a660c1
DOI: 10.1101/2025.05.18.654695

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical, Biological and Pathological Investigation of Bovine Lymphocyte Intestinal Retention Deficit (BLIRD): a new genetic disorder affecting life expectancy and immunity in Holstein dairy cattleDOI 10.1101/2025.05.18.654695Read

An endogenous retrovirus insertion disrupting bovine ALKBH8 causes a failure-to-thrive syndrome with immunodeficiency associated with juvenile mortality in Brown Swiss cattleSemantic proximity Read

A nonsense mutation in the COL7A1 gene causes epidermolysis bullosa in Vorderwald cattleSemantic proximity Read

A missense mutation in TUBD1 is associated with high juvenile mortality in Braunvieh and Fleckvieh cattleSemantic proximity Read

Selected Monogenic Genetic Diseases in Holstein Cattle-A Review.Semantic proximity Read

A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig.Semantic proximity Read

A nonsense mutation in the COL7A1 gene causes epidermolysis bullosa in Vorderwald cattle.Semantic proximity Read

An IL17RA frameshift variant in a Holstein cattle family with psoriasis-like skin alterations and immunodeficiency.Semantic proximity Read

A missense mutation in TUBD1 is associated with high juvenile mortality in Braunvieh and Fleckvieh cattleSemantic proximity Read

Massive detection of cryptic recessive genetic defects in cattle mining millions of life historiesSemantic proximity Read

NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock.Semantic proximity Read

Identification of a haplotype associated with cholesterol deficiency and increased juvenile mortality in Holstein cattle.Semantic proximity Read

Mining massive genomic data of two Swiss Braunvieh cattle populations reveals six novel candidate variants that impair reproductive success.Semantic proximity Read