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Article

Evidence that the 5'-end cap structure is essential for encapsidation of hepatitis B virus pregenomic RNA.

Journal of virology - 1 Jun 2000

Jeong J K, Yoon G S, Ryu W S

Abstract excerpt

Hepatitis B virus (HBV) replicates by reverse transcription of an RNA intermediate, the pregenomic RNA. The first step of HBV genome replication is the encapsidation of the pregenomic RNA encoding the encapsidation signal, termed epsilon, into the core particles, which is preceded by recognition and binding of HBV DNA polymerase to epsilon. The pregenomic RNA contains two identical epsilon elements due to its...

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Identifiers

PMID: 10823855
DOI: 10.1128/jvi.74.12.5502-5508.2000
PMCID: PMC112035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that the 5'-end cap structure is essential for encapsidation of hepatitis B virus pregenomic RNA.PMID 10823855Read ↗

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A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency.Semantic proximity Read ↗

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A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesisSemantic proximity Read ↗

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