Effects of W (c-kit) gene mutation on gametogenesis in male mice: agametic tubular segments in Wf/Wf testes.

doi:10.1242/dev.114.4.861

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Article

Effects of W (c-kit) gene mutation on gametogenesis in male mice: agametic tubular segments in Wf/Wf testes.

Development (Cambridge, England) - 1 Apr 1992

Koshimizu U, Watanabe D, Tajima Y, Nishimune Y

Abstract excerpt

Mutations of the W (c-kit) gene, which encodes a transmembrane tyrosine kinase receptor, affect the development and differentiation of many types of stem cell. Most homozygous W mutant mice are sterile, due to a lack of germ cells arising during embryonic development, but one of the notable excep...

Topics

Animals
Germ Cells
Male
Mice
Mice, Mutant Strains
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-kit
Seminiferous Tubules
Spermatogenesis
Testis

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