Article
Spermatogenic failure in male mice lacking H-Y antigen.
Nature - 1 Jan 2000
Burgoyne P S, Levy E R, McLaren A
Abstract excerpt
The mammalian Y chromosome carries a factor that initiates male sexual development by directing the fetal gonads to form testes. Wachtel and his colleagues proposed that this testis-determining function of the Y is mediated by the male-specific cell-surface antigen H-Y, originally defined by skin grafting. This attractive hypothesis, which has been widely accepted, was based on the assumption that serological...
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