Article
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.
Genes & development - 15 May 1996
Sonnenberg-Riethmacher E, Walter B, Riethmacher D, Gödecke S, Birchmeier C
Abstract excerpt
The c-ros gene was originally identified in mutant form as an oncogene. The proto-oncogene encodes a tyrosine kinase receptor that is expressed in a small number of epithelial cell types, including those of the epididymis. Targeted mutations of c-ros in the mouse reveal an essential role of the gene in male fertility. Male c-ros -/- animals do not reproduce, whereas the fertility of female animals is not...
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