Article
The bactericidal action of streptomycin: membrane permeabilization caused by the insertion of mistranslated proteins into the cytoplasmic membrane of Escherichia coli and subsequent caging of the antibiotic inside the cells due to degradation of these proteins.
Journal of general microbiology - 1 Mar 1992
Busse H J, Wöstmann C, Bakker E P
Abstract excerpt
The mechanism by which the aminoglycoside antibiotic streptomycin permeabilizes the cytoplasmic membrane of Escherichia coli cells was reinvestigated. For this purpose, the extent of streptomycin-induced K+ loss from cells growing at low external K+ concentrations was taken as a measure of membra...
Topics
- Biological Transport
- Cell Division
- Cell Membrane Permeability
- Dihydrostreptomycin Sulfate
- Escherichia coli
- Escherichia coli Proteins
- Ligands
- Membrane Potentials
- Mutation
- Potassium
- Protein Biosynthesis
- Protein Synthesis Inhibitors
- Ribosomal Protein S9
- Rubidium