Influence of outer membrane mutations on susceptibility of Escherichia coli to the dibasic macrolide azithromycin.

doi:10.1093/jac/29.1.27

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Article

Influence of outer membrane mutations on susceptibility of Escherichia coli to the dibasic macrolide azithromycin.

The Journal of antimicrobial chemotherapy - 1 Jan 1992

Farmer S, Li Z S, Hancock R E

Abstract excerpt

Azithromycin differs chemically from erythromycin by having an extra positive charge created by the presence of a methyl-substituted nitrogen in the 15-membered macrolide ring. This results in substantially increased potency against Gram-negative bacteria. Therefore, the possibility was considere...

Topics

Azithromycin
Bacterial Outer Membrane Proteins
Erythromycin
Escherichia coli
Membranes
Microbial Sensitivity Tests
Mutation

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