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Article

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1.

Journal of virology - 1 May 1992

Johnson P A, Miyanohara A, Levine F, Cahill T, Friedmann T

Abstract excerpt

Replication-defective mutants of herpes simplex virus type 1 (HSV-1) may prove useful as vectors for gene transfer, particularly to nondividing cells. Cgal delta 3 is an immediate-early gene 3 (IE 3) deletion mutant of HSV-1 that expresses the lacZ gene of Escherichia coli from the human cytomegalovirus immediate-early control region but does not express viral early or late genes. This vector was able to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 1373198
DOI: 10.1128/JVI.66.5.2952-2965.1992
PMCID: PMC241054

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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