Article
Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1.
Journal of virology - 1 May 1992
Johnson P A, Miyanohara A, Levine F, Cahill T, Friedmann T
Abstract excerpt
Replication-defective mutants of herpes simplex virus type 1 (HSV-1) may prove useful as vectors for gene transfer, particularly to nondividing cells. Cgal delta 3 is an immediate-early gene 3 (IE 3) deletion mutant of HSV-1 that expresses the lacZ gene of Escherichia coli from the human cytomega...
Topics
- Animals
- Cell Death
- Chromosome Aberrations
- Cytomegalovirus
- DNA Damage
- DNA, Recombinant
- Escherichia coli
- Evaluation Studies as Topic
- Fibroblasts
- Gene Expression Regulation, Viral
- Genetic Vectors
- Herpes Simplex
- Host-Parasite Interactions
- Humans
- Interferons
- Lac Operon
- Mutation
- Simplexvirus