Article
Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients.
The Journal of clinical endocrinology and metabolism - 1 Apr 1992
Fielder P J, Guevara-Aguirre J, Rosenbloom A L, Carlsson L, Hintz R L, Rosenfeld R G
Abstract excerpt
Recently, an isolated population of apparent GH-receptor deficient (GHRD) patients has been identified in the Loja province of southern Ecuador. These individuals presented many of the physical and biochemical phenotypes characteristic of Laron-Syndrome and are believed to have a defect in the GH-receptor gene. In this study, we have compared the biochemical phenotypes between the affected individuals and their...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Blotting, Western
- Carrier Proteins
- Ecuador
- Electrophoresis, Polyacrylamide Gel
- Female
- Gene Expression