Article
Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1.
Antimicrobial agents and chemotherapy - 1 Apr 1994
Kulka M, Smith C C, Levis J, Fishelevich R, Hunter J C, Cushman C D, Miller P S, Ts'o P O, Aurelian L
Abstract excerpt
An oligonucleoside methylphosphonate (ONMP) complementary to the splice acceptor site of immediate-early (IE) pre-mRNAs 4 and 5 (IE4,5SA) inhibits herpes simplex virus type 1 (HSV-1) growth in vitro and in infected animals. The antiviral effect appears to be due to inhibition of IE pre-mRNA 4 and 5 splicing and/or IE4 gene expression (M. Kulka, M. Wachsman, S. Miura, R. Fishelevich, P. S. Miller, P. O. P. Ts'o,...
Topics
- Animals
- Antiviral Agents
- Autoradiography
- Base Sequence
- Blotting, Northern
- Cell Survival
- Drug Synergism
- Genes, Immediate-Early
- Herpesvirus 1, Human
- Humans