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Article

Stabilization of Streptomyces lividans by homologous recombinational insertion.

Bio/technology (Nature Publishing Company) - 1 May 1992

Kaiser P, Flett F, Cullum J

Abstract excerpt

We have developed a system for the introduction and maintenance of novel tandem repeats in the chromosome of Streptomyces lividans 66. This was achieved by introducing, via transformation, Escherichia coli "suicide" vectors carrying manipulated S. lividans DNA fragments. Selection for antibiotic resistance markers carried on such plasmids permitted the isolation and maintenance of mutant strains containing novel...

Topics

Chromosome Deletion
Cloning, Molecular
DNA Transposable Elements
Genetic Vectors
Mutagenesis, Insertional
Mutation
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Selection, Genetic
Streptomyces

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Identifiers

PMID: 1369374
DOI: 10.1038/nbt0592-570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1369374-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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