Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene.

International journal of colorectal disease - 1 Mar 2004

Klein Wolfram, Tromm Andreas, Folwaczny Christian, Hagedorn Michaela, Duerig Natascha, Epplen Joerg T, Schmiegel Wolff H, Griga Thomas

Abstract excerpt

BACKGROUND AND AIMS: Nuclear factor kappa-B (NFkappaB) plays a crucial role in diseases associated with dysregulated immune response. NFkappaB inhibitor alpha downregulates the activity of NFkappaB. PATIENTS AND METHODS: To evaluate the contribution of the NFkappaB inhibitor alpha gene in Crohn's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Histocompatibility Antigens Class II

Share to Intracellular Signaling Peptides and Proteins

Share to NF-kappa B

Share to Nod2 Signaling Adaptor Protein

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 13680285
DOI: 10.1007/s00384-003-0531-y

Genes

NFKBIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-13680285-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene.PMID 13680285Read ↗

Lack of association of the 3'-UTR polymorphism in the NFKBIA gene with Crohn's disease in an Israeli cohort.Semantic proximity Read ↗

Mutations in CARD15 and smoking confer susceptibility to Crohn's disease in the Danish population.Semantic proximity Read ↗

Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD study.Semantic proximity Read ↗

Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes.Semantic proximity Read ↗

Contribution of CARD15 variants in determining susceptibility to Crohn's disease in Sweden.Semantic proximity Read ↗

Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms.Semantic proximity Read ↗

Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants.Semantic proximity Read ↗

TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.Semantic proximity Read ↗

Influence of CARD15 mutations on disease activity and response to therapy in 65 pediatric Crohn patients from Saxony, Germany.Semantic proximity Read ↗

Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease.Semantic proximity Read ↗

The three most common CARD15 mutations associated with Crohn's disease and the chromosome 16 susceptibility locus for systemic lupus erythematosus.Semantic proximity Read ↗

Disease duration and age influence CARD15 expression in Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.