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Article

A relationship between methylenetetrahydrofolate reductase variants and the development of invasive cervical cancer.

Gynecologic oncology - 1 Sept 2003

Gerhard D S, Nguyen L T, Zhang Z Y, Borecki I B, Coleman B I, Rader J S

Abstract excerpt

OBJECTIVE: Low red blood cell folate levels have been associated with hypomethylation of DNA in dysplastic tissue and an increased risk for cervical intraepithelial neoplasia in human papillomavirus (HPV)-infected women. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme regulating the metabolism of folate and methionine, the important components of DNA synthesis and methylation. Two common genetic...

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Source

Identifiers

PMID: 13678724
DOI: 10.1016/s0090-8258(03)00368-8

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A relationship between methylenetetrahydrofolate reductase variants and the development of invasive cervical cancer.PMID 13678724Read ↗

A case-control study of methylenetetrahydrofolate reductase polymorphisms in cervical carcinogenesis.Semantic proximity Read ↗

Association between Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer: a meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) and susceptibility for (pre)neoplastic cervical disease.Semantic proximity Read ↗

Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase polymorphism C677T and dietary folate with the risk of cervical dysplasia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia.Semantic proximity Read ↗

Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3.Semantic proximity Read ↗

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Semantic proximity Read ↗

Lack of Association between Genetic Polymorphisms in Enzymes Associated with Folate Metabolism and Unexplained Reduced Sperm CountsSemantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.Semantic proximity Read ↗

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