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Article

Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy.

BMC cardiovascular disorders - 18 Sept 2003

Hallberg Par, Lind Lars, Michaëlsson Karl, Kurland Lisa, Kahan Thomas, Malmqvist Karin, Ohman Karl Peter, Nyström Fredrik, Liljedahl Ulrika, Syvänen Ann-Christine, Melhus Hakan

Abstract excerpt

BACKGROUND: Adipocyte-derived leucine aminopeptidase (ALAP) is a recently identified member of the M1 family of zinc-metallopeptidases and is thought to play a role in blood pressure control through inactivation of angiotensin II and/or generation of bradykinin. The enzyme seems to be particularly abundant in the heart. Recently, the Arg528-encoding allele of the ALAP gene was shown to be associated with...

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Identifiers

PMID: 13678427
DOI: 10.1186/1471-2261-3-11
PMCID: PMC212555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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