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Article

Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression.

Bio/technology (Nature Publishing Company) - 1 Sept 1991

Ebert K M, Selgrath J P, DiTullio P, Denman J, Smith T E, Memon M A, Schindler J E, Monastersky G M, Vitale J A, Gordon K

Abstract excerpt

We report the first successful production of transgenic goats that express a heterologous protein in their milk. The production of a glycosylation variant of human tPA (LAtPA--longer acting tissue plasminogen activator) from an expression vector containing the murine whey acid promoter (WAP) operatively linked to the cDNA of a modified version of human tPA was examined in transgenic dairy goats. Two transgenic...

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PMID: 1367544
DOI: 10.1038/nbt0991-835

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