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Article

Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992

Morrison N A, Yeoman R, Kelly P J, Eisman J A

Abstract excerpt

Osteocalcin, the most abundant noncollagenous protein in bone, is a marker of bone turnover in normal and disease states. Its synthesis is induced by calcitriol, the active hormonal form of vitamin D, through the vitamin D receptor and a specific vitamin D-responsive element in the osteocalcin gene promoter. Serum concentrations of osteocalcin are under strong genetic influence. To ascertain whether variability...

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Identifiers

PMID: 1353882
DOI: 10.1073/pnas.89.15.6665
PMCID: PMC49563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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