Article
Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992
Morrison N A, Yeoman R, Kelly P J, Eisman J A
Abstract excerpt
Osteocalcin, the most abundant noncollagenous protein in bone, is a marker of bone turnover in normal and disease states. Its synthesis is induced by calcitriol, the active hormonal form of vitamin D, through the vitamin D receptor and a specific vitamin D-responsive element in the osteocalcin ge...
Topics
- Alleles
- Cohort Studies
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genetic Variation
- Heterozygote
- Homozygote
- Humans
- Male
- Menopause
- Middle Aged
- Osteocalcin
- Polymorphism, Restriction Fragment Length
- Receptors, Calcitriol
- Receptors, Steroid